Bone substitute materials

MinerOss™ A, MinerOss® X and MinerOss® XP

Both the ingrowth of surrounding bone tissue and the promotion of the development of low differentiated progenitor cells in bone cells are to be supported by a bone substitute material. The chemical, physical, and mechanical properties are important characteristics of a bone substitute material and define its suitability for clinical application.

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MinerOss™ A - Human Allograft Tissue Matrix

The scientific evidence shows that allografts are the second best option to patient's own bone compared to other bone substitutes.1 MinerOss™ A is a processed allogenic bone tissue that offers proven, reliable, and predictable surgical outcomes comparable to autologous bone harvested from intra-oral donor sites.

MinerOss™ A is an allograft predominantly derived from human donor femoral heads post hip replacement surgery. The donor tissue is thoroughly inspected and undergoes a strict serological screening protocol.

Thanks to its natural bone composition consisting of mineralised human collagen, MinerOss™ A shows a high biologic regeneration capability in combination with natural remodelling. Therefore, MinerOss™ A is an excellent alternative to autologous bone, meaning that there is no need for an intraoral surgical donor site, which reduces morbidity for the patient.

MinerOss™ A undergoes high safety standards in its production process and guarantees a 5-year shelf life at 5°C - 30°C.

Optimal for the following indications

Large bone defects where one bone wall is maintained can be restored to replace missing or inadequate bone tissue, or for filling or stabilizing bone defects by using MinerOss™ A in combination with a collagen membrane.

  • Regeneration of periodontal osseous defects
  • Regeneration after cyst and root tip resections
  • Regeneration of extraction sockets
  • Regeneration of gaps between alveolar wall and dental implants
  • Regeneration of gaps around block grafts
  • Sinus augmentation
  • Horizontal augmentation of alveolar ridges
  • Three-dimensional (horizontal and/or vertical) augmentation of alveolar ridges
Regeneration of extraction sockets


Filling the socket with MinerOss™ A in combination with collagen membrane regenerates bone and so retains the volume and shape of the bone over time.

Regeneration of periodontal osseous defects


A tooth with a good prognosis can be retained by regenerating lost bone, with the support of biomaterials such as MinerOss™ A in combination with collagen membrane.

Regeneration of gaps between alveolar wall and dental implants


MinerOss™ A is applied to the defect to support bone regeneration.

Product characteristics of MinerOss™ A

  • Bone from human donors (living donors: femoral heads, post-mortem donors: diaphysis)
  • Natural bone composition - mineralized human collagen
  • High biologic regeneration capability and natural remodeling
  • High safety standards
  • 5 years shelf-life at 5°C - 30°C
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Manufacturing process of MinerOss™ A

The Allotec® process

After crude removal of surrounding soft tissue, fat and cartilage, the donor tissue is brought into its final shape.

The defatting of the donor tissue allows moderate penetration of solvents during subsequent processing.

A treatment with alternating durations of diethyl ether and ethanol leaches out cellular components and denatures non-collagenic proteins, thereby inactivating potential viruses.

An oxidative treatment further denatures persisting soluble proteins, thereby eliminating potential antigenicity.

Freeze-drying preserves the natural structure of the tissue and maintains a residual moisture of <10 %, allowing quick rehydration and easy handling.

Double packing and final sterilization by gamma-irradiation guarantees a 5-year shelf-life at 5°C - 30°C.

Advantages of allografts

High patient acceptance – shorter treatment times

The scientific evidence shows that allografts are the second-best option to patient's own bone compared to other bone substitutes.1

  • Shorter surgery time: The ready-to-use allograft shortens surgery time by eliminating the need for a donor site.
  • Lower patient morbidity and less pain for the patient: Avoiding a donor site eliminates the post-operative pain associated with a second procedure.
  • Unlimited availability: It is predominantly derived from human donor femoral heads post hip replacement surgery.
  • No clinical difference in final incorporation compared to autologous bone.3, 7

Histological structure of MinerOss™ A

Histology of biopsy harvested 7 months after block augmentation3, 5, 6

Histology of biopsy harvested 7 months after block augmentation with MinerOss™ A. The allogenic bone can be recognized by the empty cavities of the osteocytes and is embedded in newly formed bone matrix.

Allogenic bone* embedded in newly formed bone. New bone matrix is lined by osteoblast (arrow) showing ongoing bone formation.

Safety and Quality

Serological testing

After thorough donor anamnesis, maximum safety is assured via a series of strict serological testing combined with C+TBA´s Allotec® purification procedure and radiological sterilization. First, serology and nucleic acid tests (NAT) are performed to identify infections before antibodies are detected in the blood. Potential viruses are inactivated, and bacteria destroyed during Allotec® purification procedure where non-collagenic proteins are denatured.

An oxidative treatment is then used to denature persisting soluble proteins and eliminate potential antigenicity. Finally, the tissue undergoes dehydration via a lyophilization technique that facilitates the sublimation of frozen water from solid phase to gas phase. This stage preserves the material’s structural integrity. The lyophilization process is an accepted and well documented procedure that preserves structural properties while improving graft incorporation.5, 6

The microscopic pores within the material ensure rapid rehydration of the tissue. The final sterilization by gamma irradiation guarantees a sterility assurance level (SAL) of 10-6 while ensuring structural and functional integrity of the product and its packaging.

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MinerOss™ A
Product Brochure

MinerOss® X

MinerOss® X is an inorganic bovine bone mineral matrix that is comparable to the mineral structure of human bone tissue. MinerOss® X is available as cortical or cancellous bone granules as well as in block form with the addition of 5% bovine collagen. The complex trabecular architecture and natural structure are designed for ideal bone formation and remodeling at the defect site.

The MinerOss® X range is used for extraction sockets, alveolar ridge enhancement, and sinus augmentations. It is available in two different grain sizes and different ampoule contents: small cancellous bone granules in sizes 0.5, 1.0, 2.0 and 4 cm3 and large granules in sizes 1.1 cm3, 2,2 cm3 and 4,4 cm3.

The blocks of the MinerOss® X Collagen are available in the following sizes: 10×11×12 mm, 8×9×9 mm, and 6×7×8 mm.

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MinerOss® XP

MinerOss® XP is an anorganic porcine bone mineral matrix designed for bone grafting. Its high porosity results in an optimal osteoconductivity and also provides adequate space for new bone buildup.

MinerOss® XP is used for alveolar ridge preservation and sinus augmentations, in extraction socket management, and for infrabony periodontal defects. It is available in two different grain sizes and different ampoule contents: small cancellous bone granules in sizes 0.25, 0.5, 1.0, and 2.0 cm³, and large granules in sizes 1.0 and 2.0 cm³.

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CAMLOG Biotechnologies GmbH may market products only upon approval by the competent authorities. 
Not all products and services may be available in every country.