Valid from November 2021 Product catalog Biomaterials
Biomaterialien Produktkatalog 2021 |1 Content Introduction 2 Biomaterials for hard and soft tissue regeneration 2 Manufacturing process – MinerOss® X/XP and Mem-Lok® RCM/Pliable 3 Bone graft substitutes 4 MinerOss® X Cancellous and MinerOss® X Collagen 4 MinerOss® XP Cancellous 6 Collagenmembranes 8 Mem-Lok® RCM – durable and long-lasting 8 Mem-Lok® Pliable – versatile and flexible 10 Reconstructive Tissue Matrix 12 NovoMatrix™ 12 Wound dressings 14 BioPlug and BioStrip 14 Auxiliary products 15 Bone Fixation Screw Kit 15 Case studies 16 Horizontal and vertical augmentation in the lower jaw with MinerOss® XP 16 Soft tissue thickening with NovoMatrix™ – the pouch technique 17 Product overview 18 Science 22 References 23
2| Biomaterials Product catalog 2021 Biomaterials for hard and soft tissue regeneration BioHorizons and Camlog are setting standards in hard and soft tissue regeneration with the bone substitute materials MinerOss® X Collagen and Granules and MinerOss® XP, the collagen membranes Mem-Lok® RCM and Mem-Lok® Pliable, and the NovoMatrix™ Reconstructive Tissue Matrix. These xenogeneic products are suitable for a broad spectrum of applications. MinerOss® X is an anorganic bovine bone mineral matrix which is comparable to the mineral structure of human bone. MinerOss® X is available as a cancellous bone granulate or in block form combined with 5% collagen. Its complex trabecular architecture and natural consistency allow for ideal bone formation at the defect site. The MinerOss® X products are used for extraction sockets, for alveolar ridge enhancement, and for sinus augmentation. MinerOss® X Particulate is available in the sizes 0.25, 0.5, 1.0 and 2.0 grams. MinerOss® X Collagen blocks are available in three sizes. MinerOss® XP is a highly porous, anorganic bone mineral of porcine origin used in bone grafting. Its high porosity provides optimal osteoconductivity and sufficient space for new bone formation [1]. The resorbable Mem-Lok® RCM collagen membrane is made from highly purified, type I collagen derived from bovine achilles tendon. Mem-Lok® is an effective barrier membrane preventing epithelial cells frommigrating into the bone defect site to support new bone formation. Mem-Lok® Pliable is a collagen membrane made from highly purified, porcine peritoneum. It has a high suture pull-out strength. Mem-Lok® Pliable resorbs in 12 to 16 weeks. Both membranes are offered in three sizes (15 x 20; 20 x 30 and 30 x 40 mm). NovoMatrix™ is an acellular dermal matrix of porcine origin used for thickening soft tissue and covering recessions. The biomaterials portfolio also includes collagen wound dressings. BioPlug and BioStrip absorb blood and other fluids to protect treated areas and to support optimal regeneration. They are mainly used to close extraction sockets and to cover smaller wounds. Clinical proven Partner of success Quality standards Novel solutions
Biomaterials Product catalog 2021 | 3 Manufacturing process MinerOss® X/XP and Mem-Lok® RCM/Pliable The main process steps during manufacture are listed below. Both the product and the production process comply with the required safety standards and requirements of the German regulations, the EU regulations as well as those of the US health authorities (FDA) as well as the safety regulations required for xenogenic processing, including EN ISO 22442-1, EN ISO 22442-2 and EN ISO 22442-3. Mem-Lok® RCM Collagen processed from bovine tendon Washed to remove processing residuals Membrane fabrication Crosslinked Remove unreacted crosslinking agent Sized, packaged and sterilized Every lot tested to meet acceptance criteria Quality control MinerOss® X/XP Receive bone tissue Clean Deproteination through heat treatment Buffer rinse Sized, packaged and sterilized Every lot tested to meet acceptance criteria Quality control Mem-Lok® Pliable Receive harvested porcine peritoneum, collagen-rich tissue Purified to remove non-collagen components Crosslinked Remove unreacted crosslinking agent Sized, packaged and sterilized Every lot tested to meet acceptance criteria Quality control
4| Biomaterials Product catalog 2021 Bovine xenogeneic bone graft substitutes MinerOss® X Cancellous and MinerOss® X Collagen The MinerOss® family of xenogeneic bone graft materials can be used in a wide variety of applications bone regeneration. It is methodically processed from bovine or porcine bone and extensively tested to eliminate potential antigenicity and to provide a favorable environment for new bone growth.* MinerOss® X is an anorganic, bovine bone, mineral matrix available in a variety of options. Physically and chemically, the product is comparable to the mineral structure of human bone. The formation and ingrowth of new bone at the implantation site of MinerOss® X is favored, due to its trabecular architecture, interconnecting macro and micro pores and its natural consistency. MinerOss® X Collagen is a combination of 95 % anorganic, cancellous, bovine bone and approximately 5 % bovine collagen. This block form allows for convenience during placement and is an ideal solution for many applications, including ridge preservation, minor bone augmentations and periodontal regeneration. Flexible for meeting clinical requirements In combination with Mem-Lok® RCM, MinerOss® X preserves ideal space and long-term cell occlusion for maximum bone volume Matrix for osseointegration Diffraction patterns are close to the mature native bone diffraction pattern [2] High porosity which supports and enhances integration of new bone Dependable stability and strength Deproteinized and delipidized, gamma-sterilized Optimal calcium/phosphate balance comparable to human bone [3] CE identification of the products 16 years on the market * Data on file by Collagen Matrix New – larger volumes
Biomaterials Product catalog 2021 | 5 The basis for good regeneration: Bimodal pore structure [2] SEM: MinerOss® X macropores and micropores resemble human bone. Data on file by Collagen Matrix5 The micropores ensure the high capillary action, and consequently the fast liquid uptake [4]. The interconnected macropores allow blood cells and proteins to enter into particles enabling effective osseointegration [4]. Volume comparison [2] Volume Fill (ml/g) Particle size 0.25–1.0 mm Particle size 1.0–2.0 mm MinerOss® X (new) 2.37 ± 0.17* 3.42 ± 0.24* MinerOss® X (old) 1.99 ± 0.08* 2.15 ± 0.07** Competitor A 2.13 ± 0.08≠ 2.91 ± 0.08≠ 40 30 20 10 0 Number (%) Pore size (mm) < 0.05 0.05–0.1 0.1–0.2 0.2–0.3 0.3–0.4 0.4–0.5 0.5–0.6 0.6–1.0 > 1.0 Competitor A MinerOss® X (old) MinerOss® X (new) * Results represent an average of 15 measurements ± S.D. ** Results represent an average of 8 measurements ± S.D. ≠ Results represent an average of 6 measurements ± S.D. There is a statistically significant difference between groups (p < 0.05).
6| Biomaterials Product catalog 2021 Porcine xenogeneic bone graft substitutes MinerOss® XP Cancellous MinerOss® XP is an anorganic porcine bone mineral matrix designed for bone grafting. Its high porosity results in an optimal osteoconductivity and also provides adequate space for new bone buildup. Intra and interparticle space [1] The highly porous structure of MinerOss® XP provides substantial space for the growth of new blood vessels and new bone. More intra and interparticular space is provided for osteoconduction and new bone formation than with comparable materials. Rough surface [1] Promotes cell adhesion and proliferation Periodontal defects Extraction sockets Horizontal ridge enhancement Sinus augmentation Vertical ridge enhancement Dehiscence defects Block graft Immediate implantation MinerOss® X Cancellous a aa aa aaa a aa a a MinerOss® X Collagen a aa a a a MinerOss® XP Cancellous aa aa aa aaa a aa a aa asuitable aa well-suited aaa very well-suited Indication-related application options
Biomaterials Product catalog 2021 | 7 SEM: MinerOss® XP macropores and micropores resemble human bone. Histologic evaluation of bone healing of adjacent alveolar sockets grafted with bovine xenogeneic bone graft materials and MinerOss® XP six months post-op – integration and bone healing [6] Histologic section of extraction socket grafted with bovine bone graft material (Trichrome stain X 20): yellow arrow = vital bone; red arrow = newly formed bone (osteoid) Histologic section of extraction socket grafted with bovine bone graft material (Trichrome stain X 10): blue arrow = bone graft material; yellow arrow = vital bone; red arrow = newly formed bone (osteoid) Histologic section of extraction socket grafted with porcine bone graft material MinerOss® XP (Trichrome stain X 10): blue arrow = bone graft material; yellow arrow = vital bone; red arrow = newly formed bone (osteoid) Histologic section of extraction socket grafted with porcine bone graft material MinerOss® XP (Trichrome stain X 20): yellow arrow = vital bone; red arrow = newly formed bone (osteoid) 100 µm 50 µm 50 µm 100 µm More space for newly formed bone [1] 1–2 mm 0.25–1 mm 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5 0 Volume per unit of weight (cm3/g) Competitor A Competitor A MinerOss® XP MinerOss® XP 1–2 mm 0.25–1 mm Of the compared materials, MinerOss® XP provides more intra and interparticle space for osteoconduction and formation of new bone [1].
8| Biomaterials Product catalog 2021 Bovine collagen membrane Mem-Lok® RCM – durable and long-lasting Mem-Lok® RCM is manufactured from highly purified, type I bovine collagen. Clinicians can be confident that Mem-Lok® RCM will serve as an effective barrier membrane for bone regeneration. Mem-Lok® RCM supports graft stabilization and bone growth by providing soft tissue support and space maintenance over a predictable timeframe. It is manufactured to ensure predictable resorption rates. Due to its in-vivo stability, it enables easy handling in demanding indications. Special handling characteristics [3] Membrane only 0.3 mm thick, yet rigid Easy to use due to dimensional stability Easy placement since membrane is not side-specific Potentially reduced treatment time thanks to easy fixation Minimal hydration for optimal bio-adaptability Properties Cell-occlusive for supporting bone regeneration Protecting the graft area from undesirable soft tissue infiltration during the initial healing phase Predictable resorption after 26 to 38 weeks [7] eliminates the need of a removal surgery Flexible, to meet clinical needs Combined with MinerOss® X and/or MinerOss® XP, Mem-Lok® RCM maintains ideal space and long-term cell occlusion for maximum bone volume Permeability permits the exchange of essential nutrients during healing Easily adapts to whole range of bone defects
Biomaterials Product catalog 2021 | 9 Periodontal defects Extraction sockets Horizontal ridge enhancement Sinus augmentation Vertical ridge enhancement Dehiscence defects Block graft Immediate implantation Mem-Lok® RCM aa aaa aaa aa aa aaa a Mem-Lok® Pliable aaa aa aa aaa a aa a asuitable aa well-suited aaa very well-suited Indication-related application options High mechanical strength [8] 350 ± 80 400 350 300 250 200 150 100 50 0 Suture pull-out strength (g) Competitor B Mem-Lok® RCM 74 ± 10 Mem-Lok® RCM: Suture pull-out strength of the collagen membrane – dense fibres provide high mechanical strength [8]. SEM Mem-Lok® RCM Membrane * The Mem-Lok® RCM membrane is preferred. In case of larger defects, the non-resorbing (form-stable) membrane is required. * *
10| Biomaterials Product catalog 2021 Porcine collagen membrane Mem-Lok® Pliable – versatile and flexible Mem-Lok® Pliable is a strong, conformable, collagen membrane made of highly purified, porcine tissue. Mem-Lok® Pliable offers flexibility and strength. It is easy to handle and simple to fixate. This barrier membrane supports soft tissue and stabilizes the grafting area. Meticulously manufactured from highly purified, intact, porcine collagen and minimally cross-linked, it is biocompatible and predictably resorbable. It is smoothly adaptable to defects and contours and can easily be repositioned. Due to its high suture pullout strength, it can be firmly anchored to the surrounding tissue. The risk of secondary infection due to BSE (bovine spongiform encephalopathy) is excluded. Special handling characteristics [5] Not side-specific Can be placed dry or hydrated Does not adhere to gloves or instruments Easily repositionable for precise placement Simple, easy fixation Single layer, intact collagen Cell occlusive High tear strength Dependable strength Proven biomechanical strength safeguards fixation In pre-clinical testing, suture pullout strength was three times higher than a comparable collagen membrane [5]. Supports wound healing [5] Reduced degree of inflammation and foreign body response confirmed in pre-clinical testing at early timepoints Protects the graft area from undesirable soft-tissue infiltration during initial healing phase Enables nutrient transfer Predictable resorption in 12 to 16 weeks Due to slower resorption rate of the compared materials, Mem-Lok® Pliable provides greater initial stability during the crucial weeks of early healing
Biomaterials Product catalog 2021 | 11 * The Mem-Lok® RCM membrane is preferred. In case of larger defects, the non-resorbing (form-stable) membrane is required. High mechanical strength [5] 953 ± 110 1000 900 800 700 600 500 400 300 200 100 0 Suture pull-out strength (g) Competitor B Mem-Lok® Pliable 330 ± 120 Mem-Lok® Pliable: Suture pull-out strength of the collagen membrane – dense fibres provide high mechanical strength [8]. SEM Mem-Lok® Pliable Membrane: not side-specific; dense, uniform single layer [2] Periodontal defects Extraction sockets Horizontal ridge enhancement Sinus augmentation Vertical ridge enhancement Dehiscence defects Block graft Immediate implantation Mem-Lok® RCM aa aaa aaa aa aa aaa a Mem-Lok® Pliable aaa aa aa aaa a aa a asuitable aa well-suited aaa very well-suited Indication-related application options * *
NovoMatrix™ is an acellular dermal matrix derived from porcine tissue. In surgical application, the tear-resistant and easy-to-handle [9, 10] matrix is an excellent alternative to autologous connective tissue grafts (CTG). There is no need for an intraoral surgical donor site, which reduces morbidity for the patient. Owing to the manufacturing process, the matrix is free of donor cells. At the same time, the structure of the source tissue remains virtually unchanged, thus supporting the ingrowth of cells and micro-vessels. Proprietary tissue processing enables optimal cell repopulation and revascularization through gentle preparation, resulting in esthetic soft tissue regeneration [11]. NovoMatrix™ is supplied pre-hydrated in a patented aqueous phosphate-buffered solution containing matrix stabilizers and can therefore be used promptly without requiring extensive rehydration [12]. Reconstructive tissue matrix NovoMatrix™ Optimal for the following indications [12] Increase in attached tissue around teeth and implants Reconstruction of the alveolar ridge for prosthetic restoration Guided tissue regeneration in recession defects for root coverage 12| Biomaterials Product catalog 2021 Advantages of NovoMatrix™ application Shorter surgery time The ready-to-use collagen matrix shortens surgery time by eliminating the need for a second donor site [13]. Lower patient morbidity Avoiding a donor site on the palate eliminates the post-operative pain associated with a second procedure [13–15]. Excellent tissue integration The application of NovoMatrix™ supports rapid revascularization, cellular repopulation and minimal inflammatory reactions [11, 16–18]. Natural tissue and color structure The application of NovoMatrix™ demonstrates irritation-free healing and very good adaptation of the color and tissue structure to the natural surrounding tissue [19]. Rapid and complication-free healing of soft tissue The application of NovoMatrix™ supports a positive immunological reaction as well as tissue integration and regeneration [11, 17, 18, 20]. Product characteristics of NovoMatrix™ The LifeCell™ tissue preparation process results in rapid revascularization. Consistent tissue thickness at all times Pre-hydrated – ready-to-use out of the package following a 2-minute soak in sterile saline or lactated Ringer’s solution [12] Store at –8 °C to +30 °C [12]
Biomaterials Product catalog 2021 | 13 LifeCell™ – over 25 years of experience For over two decades LifeCell™ has been developing innovative products for a wide range of applications. With over 2.5 million grafts to date, 25 years of experience in tissue processing and an ongoing commitment to innovation, LifeCell™ has joined forces with BioHorizons and Camlog to bring NovoMatrix™, the next generation soft-tissue augmentation material to dentistry. 2000 BioHorizons begins distribution of AlloDerm™ RTM for dentistry (U.S.) 2005 AlloDerm™ RTM for guided bone regeneration (U.S.) 2019 NovoMatrix™ Reconstructive Tissue Matrix for applications in dentistry (EU)* 1986 Foundation of the LifeCell™ Corporation * NovoMatrix™ is cleared for sale in the European Union. Success factor processing methods Tissue selection Manufactured from targeted porcine tissue for desired mechanical and handling properties. Dermis isolation Non-chemical based method that removes all non-dermal tissue retaining the structural integrity of the matrix. Microbial neutralization Proprietary process removes 99.9 % of the pathogens, enabling a more gentle preparation process. Decellularization & enzyme treatment Maintains the natural collagen structure while extracting the porcine alpha-gal antigen, as well as the cell and DNA components to minimize the xenogenic immune response. Matrix preservation The proprietary preparation process stabilizes the key matrix proteins as well as protecting the integrity of the acellular dermal matrix, thus providing a platform for tissue regeneration. Sterilization Optimized steriliza- tion process to preserve the natural tissue structure, thus retaining the regenerative properties of the acellular dermal matrix. Regeneration An intact acellular dermal matrix derived from porcine tissue that retains the biochemical components that support a positive immunological response and regeneration [17, 21, 22]. Histological structure of NovoMatrix™ 100 µm Histological structure of human dermis 100 µm Further information, videos and clinical case studies at www.biohorizonscamlog.com/novomatrix
14| Biomaterials Product catalog 2021 Bovine collagen wound dressings BioPlug and BioStrip BioPlug and BioStrip are wound dressings made from bovine collagen. They are designed to absorb blood or fluids and to protect the wound, thus supporting optimal healing. Collagen supports the formation of the blood coagulum and contributes to a rapid stabilization of the wound area [23]. Because of their haemostyptic effect, collagen wound dressings are used for the stabilization of extraction sockets and biopsy sampling points as well as in the treatment of smaller wounds. Fully resorbable in 10 to 14 days 10 units per pack Packaged sterile BioPlug – applications include Extraction sockets Biopsy sites BioStrip – applications include Closure of grafted sites Dressing of minor wounds Pressure sores of dentures Canker sores (non-infected and viral) Periodontal surgery wounds Sutures Burns Extraction sites Surgical wounds Traumatic wounds BioPlug aaa aaa aaa aaa aaa aaa aaa aaa BioStrip aaa aaa aaa aaa aaa aaa aaa aaa asuitable aa well-suited aaa very well-suited Indication-related application options
Biomaterials Product catalog 2021 | 15 Indicated for use in fixation of cortical onlay grafts and meshes and for membrane tenting used in Guided Bone Regeneration (GBR). The kit is compact and conveniently organized for efficient retrieval of instruments and screws. Includes cortical bone drills for both latch-type and frictiongrip (FG) handpieces. Das Bone Fixation Screw Kit includes Flexible micro mesh Screwdriver body Comprehensive instrument set Autoclavable screw block with lid 24 screws: – 6 Micro screws, 1.4 x 8.0 mm – 6 Micro screws, 1.4 x 10.0 mm – 6 Mini screws, 2.0 x 10.0 mm – 6 Mini screws, 2.0 x 12.0 mm Instruments available for reordering Micro screwdriver shaft for screwdriver body Micro screwdriver shaft for latch-type handpieces Micro drill bit for latch-type handpieces, 1.0 mm Mini screwdriver shaft for screwdriver body Mini screwdriver shaft for latch-type handpieces Mini drill bit for latch-type handpieces, 1.6 mm Mini drill bit for handpieces with friction-grip shaft (Ø 2.35 mm), 1.6 x 67.0 mm Screwdriver body Screws available for reordering Micro screws, 1.4 x 4.0 mm (pack of 6) Micro screws, 1.4 x 6.0 mm (pack of 6) Micro screws, 1.4 x 8.0 mm (pack of 6) Micro screws, 1.4 x 10.0 mm (pack of 6) Micro screws, 1.4 x 12.0 mm (pack of 6) Mini screws, 2.0 x 8.0 mm (pack of 6) Mini screws, 2.0 x 10.0 mm (pack of 6) Mini screws, 2.0 x 12.0 mm (pack of 6) Mini screws, 2.0 x 14.0 mm (pack of 6) Mesh available for reordering Micro mesh for Guided Bone Regeneration 24 x 35 mm; 0.1 mm thick Auxiliary products Bone Fixation Screw Kit
16| Biomaterials Product catalog 2021 * Dr. Sangeeta Pai, Oldenburg Case studies Horizontal and vertical augmentation in the lower jawwith MinerOss® XP* The bone substitute material (MinerOss® XP) was mixed with blood from the surgical site and wetted with liquid L-PRF. Autologous blood therapy not only supports wound healing and tissue regeneration, but also simplifies handling when inserting the bone particles. The interdental gap in the 4th quadrant was to be reconstructed with the aid of implants. To create a sufficiently stable implant bed, both horizontal as well as vertical bone augmentation was essential. After exposure of the alveolar bone, it was ”freshened“. These malleable sticky ”blocks“ could be applied easily to the deficient alveolar bone and modeled. The advantage of this procedure is that a larger area can be augmented as the bone substitute particles are incorporated in the coagulum. Saturation with liquid L-PRF was performed with a raspatory, by slightly lifting the mixture of blood and bone substitute material from all sides. This resulted in the shape of a ”block“, which stabilized and coagulated after a short period of time. At the time of implant placement (four months after the augmentative measures), the alveolar bone had been clearly widened and was stable. The healthy, newly formed bone tissue formed the perfect basis for reconstruction with implants. A resorbable barrier membrane (Mem-Lok® Pliable) was inserted. This has a service life of up to 16 weeks and prevents epithelial cells from growing into the augmentation.
Biomaterials Product catalog 2021 | 17 * Dr. Roman Beniashvili, Schorndorf Soft tissue thickening with NovoMatrix™ – the pouch technique* Initial situation: referral for an immediate restoration due to root remnants which were not worth preserving. After removal of the root and cleaning of the alveolus, bone replacement material was inserted to stabilize the facial lamella. A CAMLOG® PROGRESSIVE-LINE Implant was placed prosthetically oriented into the palatal alveolar wall. At over 30 Ncm, primary stability was sufficient for the planned immediate restoration. Using the crestal access, a pouch was prepared up to the mobile mucosa without a vertical incision. The NovoMatrix™ was pierced and pulled into the cavity using a suture. To thicken the vestibular mucosa and achieve attached soft tissue, NovoMatrix™ was cut to fit the defect size. Six weeks after the surgical procedure, the peri-implant tissue was stable and the surgical site had almost completely healed. The definitive, palatally screw-retained hybrid abutment crown could be placed. The tear-resistant matrix was fixed deep in the vestibulum with a button suture and adapted to the alveolar bone. A gingiva former supported the tissue up to insertion of the temporary immediate restoration.
18| Biomaterials Product catalog 2021 MinerOss® X Cancellous (bovine bone graft substitute) Art. No. Weight / Volume Particle size MINX-CAN0.25GR 0.25 g / 0.6 cm3 250–1000 µm MINX-CAN0.5GR 0.5 g / 1.2 cm3 250–1000 µm MINX-CAN1.0GR 1.0 g / 2.4 cm3 250–1000 µm MINX-CAN2.0GR 2.0 g / 4.7 cm3 250–1000 µm MINX-CAN0.25GRL 0.25 g / 0.9 cm3 1000–2000 µm MINX-CAN0.5GRL 0.5 g / 1.7 cm3 1000–2000 µm MINX-CAN1.0GRL 1.0 g / 3.4 cm3 1000–2000 µm MINX-CAN2.0GRL 2.0 g / 6.8 cm3 1000–2000 µm MinerOss® X Cancellous Syringe (Applicator) Art. No. Volume Particle size MINX-SYR0.5 0.5 cm3 250–1000 µm Art.-Nr. Product size MINX-COLLAGEN-SM 6 x 7 x 8 mm MINX-COLLAGEN-MED 8 x 9 x 9 mm MINX-COLLAGEN-LG 10 x 11 x 12 mm MinerOss® X Collagen (1 block 95 % MinerOss® X granulate + 5 % bovine collagen) MinerOss® XP Cancellous (porcine bone graft substitute) Art. No. Volume Particle size MINXP-CAN0.5SM 0.5 cm3 250–1000 µm MINXP-CAN1.0SM 1.0 cm3 250–1000 µm MINXP-CAN2.0SM 2.0 cm3 250–1000 µm MINXP-CAN4.0SM 4.0 cm3 250–1000 µm MINXP-CAN1.0LG 1.0 cm3 1000–2000 µm MINXP-CAN2.0LG 2.0 cm3 1000–2000 µm MinerOss® XP Cancellous Syringe (Applicator) Art. No. Volume Particle size MINXP-SYR0.5 0.5 cm3 250–1000 µm Product overview Bone graft substitutes New Larger volumes
Biomaterials Product catalog 2021 | 19 Collagen membranes Mem-Lok® RCM (bovine collagen membrane) Art. No. Product size RCM-ML1520 15 x 20 mm RCM-ML2030 20 x 30 mm RCM-ML3040 30 x 40 mm 15 x 20 mm 30 x 40 mm 20 x 30 mm Mem-Lok® Pliable (porcine collagen membrane) Art. No. Product size PBLE-ML1520 15 x 20 mm PBLE-ML2030 20 x 30 mm PBLE-ML3040 30 x 40 mm Reconstructive tissue matrix NovoMatrix™ (porcine, acellular dermal matrix) Art. No. Product size NOV1515 15 x 15 mm NOV1525 15 x 25 mm NOV1545 15 x 45 mm NOV2545 25 x 45 mm 15 x 15 mm 25 x 45 mm 15 x 25 mm 15 x 45 mm
20| Biomaterials Product catalog 2021 Auxiliary products Bone Fixation Screw Kit Art. No. Contents 160-900 Micro mesh, screwdriver body, instrument set, screw block, screws Instruments Art. No. Article BS-MCSSFT-HND Micro screwdriver shaft for screwdriver body BS-MCSSFT-ANG Micro screwdriver shaft for latch-type handpieces BS-1MCDB-ANG Micro drill bit for latch-type handpieces, 1.0 mm BS-MNSSFT-HND Mini screwdriver shaft for screwdriver body BS-MNSSFT-ANG Mini screwdriver shaft for latch-type handpieces BS-16MMDB-ANG Mini drill bit for latch-type handpieces, 1.6 mm BS-16X67MDB-STR Mini drill bit for handpieces with friction-grip shaft (Ø 2.35 mm), 1.6 x 67.0 mm BS-SDRIVER Screwdriver body Product overview Collagen wound dressings BioPlug and BioStrip (bovine collagen wound dressings) Art. No. Product size Pack size BIOPLUG 10 x 20 mm Pack of 10 BIOSTRIP 25 x 75 mm Pack of 10 25 x 75 mm (BioStrip)
Implant pass The implant pass documents that the patient received high-quality BioHorizons biomaterials from a highly trusted source: BioHorizons Camlog. In addition, it gives important information on behavior following implantation and on care of the prosthetic restoration. Biomaterials Product catalog 2021 | 21 Screws Art. No. Article Pack size BSV-14X4 Micro screws, 1.4 x 4.0 mm Pack of 6 BSV-14X6 Micro screws, 1.4 x 6.0 mm Pack of 6 BSV-14X8 Micro screws, 1.4 x 8.0 mm Pack of 6 BSV-14X10 Micro screws, 1.4 x 10.0 mm Pack of 6 BSV-14X12 Micro screws, 1.4 x 12.0 mm Pack of 6 BSV-2X8 Mini screws, 2.0 x 8.0 mm Pack of 6 BSV-2X10 Mini screws, 2.0 x 10.0 mm Pack of 6 BSV-2X12 Mini screws, 2.0 x 12.0 mm Pack of 6 BSV-2X14 Mini screws, 2.0 x 14.0 mm Pack of 6 Mesh Art. No. Article BS-MMESH Micro mesh for Guided Bone Regeneration 24 x 35 mm; 0.1 mm thick
22| Biomaterials Product catalog 2021 Science It's the cells that make the decision Functionality of biomaterials results from their optimal biological interactions with tissue cells. Bone is a structure difficult to duplicate. Research in tissue engineering, especially in nano topography, can lead to improved biomaterials. There are numerous biomaterials available, some of natural origin, others of synthetic origin. When choosing a biomaterial, many factors come into play next to functionality. From a biological point of view, the ideal biomaterial should promote formation of a stable blood coagulum. It should be functional, biocompatible, and it should favor healing processes. Autogenous bone is still the gold standard in grafting. However, it is linked to higher costs, longer treatment times and it requires an additional surgical procedure possibly leading to increased donor site morbidity. This needs to be considered when carrying out augmentation procedures. Therefore, the possibilty of reducing potential complications is an important factor. Easy handling of the materials is of advantage for the clinician. Aside from these decisive factors, it must not be forgotten that bone augmentation surgery is often performed as a part of dental implant surgery. Therefore, different biological aspects should be considered when choosing biomaterials. Comparative studies have shown that different biomaterials can be safely used [7]. The needs and preferences of the treating clinician play as important a role as the indication, the requirements of the patient, as well as time and costs. In the end, selection of the appropriate biomaterial must be made with the knowledge of its properties and its clinical outcome. The goals are always predictable results and clinical success. Conclusion: Prior to using a biomaterial, it is recommended to balance and consider the biological interaction between the biomaterial and the endogenous cells [24] – it’s the cells that make the decision.
Biomaterials Product catalog 2021 | 23 References [1] Data on file, Shu-Thung Li, Ph. D. et al.: Isolation and Characterization of a Porous Carbonate Apatite From Porcine Cancellous Bone. Science, Technology, Innovation, Aug. 2014: 1–13. [2] Shu-Tung Li, Hui-Chen Chen and Debbie Yuen: Comparison of a New Natural Bovine Bone Mineral (Carbonate Apatite Anorganic Bone) to Currently Marketed NuOss™ and Bio-Oss®: In Vitro and In Vivo Evaluations. Collagen Matrix, Inc., Oakland, New Jersey 07436. [3] Gonshor A, Chris L Tye: Evaluation of Anorganic Bovine Bone Mineral in Post-extraction Alveolar Sockets: A Case Series. Journal of Osseointegration, March 2010; 1(2). [4] I. Sopyana, M. Melb, S. Rameshc, K.A. Khalidd: Porous hydroxyapatite for artificial bone applications. Science and Technology of Advanced Materials 8 (2007); 116–123. [5] Data on file, Li ST, Yuen D, Martin D, Lee NS: A comparative study of a new porcine collagen membrane to BioGide®. Science, Technology, Innovation. February 1–5, 2015. [6] Renzo Guarnieri et al.: Histologic evaluation of bone healing of adjacent alveolar sockets grafted with bovine- and porcine-derived bone: a comparative case report in humans. Regenerative Biomaterials, 2017, 1–4 doi: 10.1093/rb/rbx002. [7] Data on file, Debbie Yuen et al.: Prediction of in vivo stability of a resorbable, reconstituted type I collagen membrane by in vitro methods. World Biomaterials Congress Transactions, Sixth World Biomaterials Congress Transactions. Collagen Matrix Inc., Franklin Lakes, NJ 07417 USA [8] Yuen D, Junchaya et al.: A resorbable, reconstituted type I collagen membrane for guided tissue regeneration and soft tissue augmentation. Society for Biomaterials. 2000; 1228. [9] Data on file, Allergan. NovoMatrix™ – Mechanical testing, Preclinical Data. [10] Data on file, Allergan. INT/0204/2018. [11] Suárez-López Del Amo F, Rodriguez JC, Asa‘ad F, Wang HL. Comparison of two soft tissue substitutes for the treatment of gingival recession defects: an animal histological study. J Appl Oral Sci., 2019;27:e20180584. [12] Reference manufacturer’s Instructions for Use (IFU) package insert. [13] Griffin T, Cheung W, Athanasios Z, Damoulis P. Postoperative Complications Following Gingival Augmentation Procedures. J Periodontology 2006;77:2070-2079. [14] Aguirre-Zorzano LA, García-De La Fuente AM, Estefanía-Fresco R, Marichalar-Mendía X. Complications of harvesting a connective tissue graft from the palate. A retrospective study and description of a new technique. J Clin Exp Dent. 2017;9(12):e1439-45. [15] Tavelli L, Asa’ad F, Acunzo R, Pagni G, Consonni D, Rasperini G. Minimizing Patient Morbidity Following Palatal Gingival Harvesting: A Randomized Controlled Clinical Study. The International Journal of Periodontics & Restorative Dentistry 38(6):e127-e134 · November 2018. [16] Harper JR, McQuillan DJ. Extracellular wound matrices: a novel regenerative tissue matrix (RTM) technology for connective tissue reconstruction. Wounds. 2007;19(6):163-168. [17] Sandor M, Leamy P, Assan P, et al. Relevant in vitro predictors of human acellular dermal matrix-associated inflammation and capsule formation in a nonhuman primate subcutaneous tissue expander model. Eplasty. 2017;17:e1-e21. [18] Xu H, Wan H, Sandor M, et al. Host response to human acellular dermal matrix transplantation in a primate model abdominal wall repair. Tissue Eng Part A. 2008;14(2):2009-2019. [19] Van Orten A. Peri-implant thickening of soft tissue – stable and functional. Implantologie Journal 5 | 2020. [20] Sandor M, Xu H, Connor J, et al. Host response to implanted porcine-derived biologic materials in a primate model of abdominal wall repair. Tissue Eng Part A. 2008;14(12):2021-2031. [21] Data on file, Allergan. LRD2011-08-015. [22] Data on file, Allergan. LRD2013-02-004. [23] Nuyttens BP et al.: Platelet adhesion to collagen. Thromb Res. 2011 Jan; 127. [24] Scott J. Roberts et al.: The combined bone forming capacity of human periosteal derived cells and calcium phosphates. Biomaterials 32, 2011; 4393–4405.
24| Biomaterials Product catalog 2021 Validity: Upon its release, this literature supersedes all previously published versions. Availability: BioHorizons continually strives to improve its products and therefore reserves the right to improve, modify, change specifications or discontinue products at any time.
Rights to change reserved · M-0268-CAT-EN-INT-BHCL-01-102021 Customer number: Distributors For further information about the distributors in 90 countries, please visit www.biohorizons.com Headquarters CAMLOG Biotechnologies GmbH | Margarethenstr. 38 | 4053 Basel | Switzerland Phone +41 61 565 41 00 | Fax +41 61 565 41 01 | info@camlog.com | www.camlog.com MinerOss® X, MinerOss® XP, Mem-Lok® RCM and Mem-Lok® Pliable are manufactured by Collagen Matrix, Inc. BioPlug and BioStrip are manufactured by NovaBone Products, LLC. AlloDerm™ is a trademark of LifeCell™ Corporation, an Allergan affiliate. CAMLOG® is a registered trademark of CAMLOG Biotechnologies GmbH. BioHorizons®, MinerOss® and Mem-Lok® are registered trademarks of BioHorizons. NovoMatrix™ is a trademark of BioHorizons. They may, however, not be registered in all markets. As applicable, BioHorizons products are cleared for sale in the European Union under the EU Medical Device Directive 93/42/EEC and the human tissues and cells Directive 2007/47/EC. We are registered to ISO 13485:2016, the international quality management system standard for medical devices, which supports and maintains our product licenses with Health Canada and in other markets around the globe. Original language is English. ©BioHorizons. All rights reserved. Not all products shown or described in this literature are available in all countries.
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